May 25, 2015
"With monsoon season coming, there are hundreds and thousands of people without permanent shelter, so finding shelter solutions over the next two months will be extremely important, especially in rural areas," warned Mark Smith, senior director of emergency affairs at World Vision.
Clean water – especially in light of the upcoming monsoon season – is of major concern in Nepal.
Water is already fairly scarce within the Kathmandu valley even at the best of times.
Moreover, with Nepalis resorting to camping outdoors, the lack of proper hygiene facilities and broken sewage systems heighten the risk of diarrheal disease epidemics.
The World Health Organization (WHO) estimates that only 27 percent of the population has access to adequate sanitation, adding that diarrheal diseases, dysentery, cholera and typhoid are the primary causes of death in the country
PLOS Medicine, a peer-reviewed weekly medical journal covering the full spectrum of medical sciences, just published its latest evaluation of Nepal after the recent earthquakes and the vaccine-preventable diseases looming on Nepal’s horizon. PLOS’s dispatch was written by Lorenz von Seidlein and posted on May 21, 2015:
In the wake of the recent devastating earthquakes, PLOS Medicine Consulting Editor Lorenz von Seidlein visited Nepal to assess outbreak risks. Lorenz travelled with Anuj Bhattachan, International Vaccine Institute, Seoul, Korea and guidance from Deepak C. Bajracharya and Shyam Raj Upreti from the Group for Technical Assistance, Kathmandu, Nepal. The assessment was requested by the epidemiology and disease control division of the Ministry of Health of Nepal and facilitated by Stop Cholera. Here he reports on the damage he witnessed and considers the choice of administering vaccines pre-emptively versus reactively in response to an outbreak.
The two earthquakes in April and May 2015 seem to have selectively erased much of northern Nepal’s architecture and history. Many buildings in urban Kathmandu were constructed during the last 20 years. These buildings, in many cases multi-storey or high-rise, did not collapse during the recent earthquakes. The older buildings in urban Kathmandu are brick and mortar constructions without a frame. These vintage structures give Kathmandu its characteristic charm but they fell like dominoes during the first earthquake on 25th April. In rural districts the buildings are mostly stone and clay; they are perfectly adapted for the high altitude climate of the Himalayas but offer very little resistance against an earthquake. Most of the stone houses completely crumbled or have large enough cracks to suggest imminent collapse. According to government figures, 488,579 houses were destroyed and 260,026 damaged. The probability of a quick reconstruction is small because of the widespread damage. Furthermore, majority of men of working age are employed abroad, leaving a denuded local labour force.1
[Current estimates suggest that more than 8,600 people died and nearly 18,000 people were injured in the two quakes.. As it stands] most health care is required for acute trauma but trauma will be replaced by other presentations during the coming months. Water resources of the 660,000 to 1.3 million people were affected and between 850,000 to 1.7 million need sanitation support. Concurrently 945 health facilities, mostly village health posts, are partially or totally damaged. Health services have been severely compromised. Routine childhood vaccinations had to be suspended in some districts. The makeshift temporary living conditions, disruptions to water supply and sanitation, and strained health services foreshadow an aftershock of a different variety: enteric diseases may seize this opportunity to spread through an already devastated country.
Enteric diseases are infections caused by viruses and bacteria that enter the body through the mouth or intestinal system, primarily as a result of eating, drinking and digesting contaminated foods or liquids. Direct contact with contaminated feces or vomit is a secondary method of contracting enteric ailments. The name for this class of diseases is derived from the Greek word enteron, which means intestine. Cholera, typhoid fever, salmonella and Escherichia coli, or E.coli, infections are some of the most common enteric diseases.
Two vaccine preventable enteric diseases are endemic in Nepal and have potential for outbreaks. Kathmandu is considered by some the typhoid fever capital of the world. The transmission of the typhoidal Salmonella species is facilitated by poor hygiene and public sanitation conditions. Although the Vi polysaccharide typhoid vaccine was found to be safe and effective in clinical trials in Nepal in 1987, to this day immunization against typhoid fever has not been included into the country’s public health armamentarium.
Cholera is another enteric disease endemic in Nepal that has a high outbreak potential. The largest recent cholera outbreak in Nepal occurred in Jajarkot district in 2009. More than 30,000 reported cases and 500 cholera deaths were reported during the outbreak in Jajarkot and surrounding areas in 2009. In 2014 a cholera outbreak was reported in Rautahat district in the low altitude region of Nepal bordering India. In response the MoH undertook a vaccination campaign with oral cholera vaccine (OCV) which has become available through a stockpile mechanism administered by the WHO. This mechanism allows countries to quickly obtain low-cost vaccines including OCV, meningococcal and yellow fever vaccine.
There are some mitigating circumstances which could reduce the risk for cholera outbreaks. For example, the landslides, which have made access to the northern villages impossible, also likely prevent importation of cholera into these remote villages. During our assessments of areas outside Kathmandu, we witnessed helicopter deliveries of food and basic medicines by airdrops. On the other hand, should a cholera outbreak occur in these isolated areas, it may take weeks before it is detected and a response mounted. Such delays will result in high case fatality rates.
The availability of a safe and protective vaccine against cholera has raised a debate whether OCVs should be used reactively (in response to an outbreak) or pre-emptively (to prevent an outbreak) during the post-earthquake period in Nepal. Of course prevention is smarter, but the damage is widespread; who should receive the vaccine? Predicting where a cholera outbreak will occur remains impossible, the total amount of OCV on the world market is limited, the population currently at high risk for cholera secondary to the earthquake is much larger than the available product, and the vaccine and its administration costs money.
Most importantly, large vaccination campaigns are more technically challenging during the aftershocks of a massive earthquake and in isolated areas where access is difficult. Earlier this week we visited a district health officer in Gorkha— one of the most severely affected districts— who had no time to talk with us. When he finally had two minutes available, he told tell us that he is overwhelmed by the demands of disaster management, there are (at the moment) no cholera cases in his district, and a cholera vaccination campaign was simply not on the cards. A range of emergency measures had precedence on this day and will have precedence in the weeks to come. In the absence of evidence and experience policymakers are reluctant to select one community over another.
Reactive oral cholera vaccination seems to be the more feasible alternative if the detection of cholera cases and an immediate response can be guaranteed. Reactive vaccinations rely on accurate and complete surveillance. The current Nepalese cholera surveillance protocol demands the immediate reporting of suspected cholera cases (i.e. watery diarrhoea) by the health posts to the district health centre, which are then forwarded to national health laboratory, which will send transport media for sample collection to the affected health post and return the samples to the laboratory. The results are reported to the MoH, which takes appropriate action. That this process can fail was demonstrated in Jajarkot district in 2009 when no earthquake had happened. Cholera cases have to be detected rapidly for timely measures (case management, water supply, sanitation, hygiene education as well as vaccination) to be put in place. Oral cholera vaccination campaigns will require the completion of paperwork, approval by an international coordinating group, shipment of vaccines, planning and implementation of a vaccine campaign. Under optimal circumstances this process can take two months. Circumstances in Nepal are currently not optimal for a rapid response. If a cholera epidemic is progressing slowly, a linear increase in the number of new cases can be manageable. If the number of cases increases at an exponential rate, the containment of the outbreak is unlikely and a catastrophic outbreak similar to the cholera outbreak in Zimbabwe 2008-2009 or Haiti 2010-2011 is the more likely scenario.
There is no easy solution. At the moment the path of least resistance is to ramp up surveillance as much as possible to be able react to an outbreak as quickly as possible. Considering the current circumstances, the shocks to the health care system, and the priority for reconstruction nobody will object to such an approach. Yet if this plan doesn’t work out and cholera spreads we will regret the decision not having acted pre-emptively. Indeed the majority of mass cholera vaccination campaigns have been pre-emptive. Considering the damage and the suffering caused by the recent large cholera outbreaks in Zimbabwe and Haiti a large pre-emptive campaign may be the best solution for Nepal.